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Special Issue "Chemistry of Phytocolloids"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 August 2023 | Viewed by 2479

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Special Issue Editors

Dr. Caio Pinho Fernandes

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Department of Biological and Health Sciences, Federal University of Amapá, Campus Marco Zero, Macapá 68903-419, AP, Brazil
Interests: phytopharmaceutical nanobiotechnology; nano-emulsions; nanodispersions; essential oils; amazon oils; terpenes

Prof. Dr. Leandro Rocha

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Guest Editor

Department of Pharmaceutical Technology, Faculty of Pharmacy, Fluminense Federal University, Rua Dr. Mário Viana, 523, Santa Rosa, Niterói 24.241-000, RJ, Brazil
Interests: biotechnology; natural products; pharmacognosy

Dr. Deborah Quintanilha Falcão

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Dr. Samanta Cardozo Mourão

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Faculty of Pharmacy, Fluminense Federal University, Rua Dr. Mario Viana, 523, Santa Rosa, Niterói 24241-000, RJ, Brazil
Interests: nano-emulsion; solid self-emulsifying drug delivery system; natural polymers; biopharmaceutics

Special Issue Information

Dear Colleagues,

We have been aware of the ability of some natural products (NP) to exert interesting properties (e.g., anethole in droplets of Arak after its self-emulsification or foam properties of a saponin) for a very long time. A growing number of studies have been published in the field of colloids with organic compounds from the secondary metabolism of living organisms, this unique skeleton diversity being responsible for a wide range of possibilities and also for the challenges in term of generation/stabilization of the colloids. In spite of this versatility, several papers fail to engage in deep discussion about the theoretical background and interfacial phenomena. Therefore, the aim of this Special Issue is to focus on papers that contribute to the front matter and state of the art of Chemistry of Phytocolloids. Topics of interest include:

Phase transitions;
Crystal liquids, microemulsions;
Emulsions, nano-emulsions;
Foams;
Self-assembly and supramolecular structures;
Prediction of HLB by QSPR;

Studies with nanoparticles and/or other systems or NP delivery, including practical applications, are also welcome only if accompanied by a deep theoretical background and interfacial phenomenon description. Studies that are not related to NP will not be covered in this Special issue.

Dr. Caio Pinho Fernandes
Prof. Dr. Leandro Rocha
Dr. Deborah Quintanilha Falcão
Dr. Samanta Cardozo Mourão
Guest Editors

Manuscript Submission Information

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Published Papers (3 papers)

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Research

Open AccessFeature PaperArticle

Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

Francisco Paiva Machado

Diogo Folly

Ricardo Esteves

Bettina Monika Ruppelt

Victoria Marques da Silva

Ana Paula dos Santos Matos

José Augusto Albuquerque dos Santos

Leonardo da Silva Rangel

Marcelo Guerra Santos

Natalia Lidmar von Ranke

Carlos Rangel Rodrigues

Eduardo Ricci-Junior

Leandro Rocha

and

Robson Xavier Faria

Molecules 2023, 28(16), 5944; https://doi.org/10.3390/molecules28165944 (registering DOI) - 08 Aug 2023

Viewed by 106

Abstract

Schistosomiasis is a tropical disease transmitted in an aqueous environment by cercariae from the Schistosoma genus. This disease affects 200 million people living in risk areas around the world. The control of schistosomiasis is realized by chemotherapy, wastewater sanitation, health education, and mollusk control using molluscicidal agents. This work evaluates the effects of a nanoemulsion containing essential oil from Myrciaria floribunda leaves as a molluscicidal and cercaricidal agent against Biomphalaria glabrata mollusks and Schistosoma mansoni cercariae. The Myrciaria floribunda essential oil from leaves showed nerolidol, β-selinene, 1,8 cineol, and zonarene as major constituents. The formulation study suggested the F3 formulation as the most promising nanoemulsion with polysorbate 20 and sorbitan monooleate 80 (4:1) with 5% (w/w) essential oil as it showed a smaller droplet size of approximately 100 nm with a PDI lower than 0.3 and prominent bluish reflection. Furthermore, this nanoemulsion showed stability after 200 days under refrigeration. The Myrciaria floribunda nanoemulsion showed LC₅₀ values of 48.11 µg/mL, 29.66 µg/mL, and 47.02 µg/mL in Biomphalaria glabrata embryos, juveniles, and adult mollusks, respectively, after 48 h and 83.88 µg/mL for Schistosoma mansoni cercariae after 2 h. In addition, a survival of 80% was observed in Danio rerio, and the in silico toxicity assay showed lower overall human toxicity potential to the major compounds in the essential oil compared to the reference molluscicide niclosamide. These results suggest that the nanoemulsion of Myrciaria floribunda leaves may be a promising alternative for schistosomiasis control. Full article

(This article belongs to the Special Issue Chemistry of Phytocolloids)

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Open AccessArticle

Larvicidal Effect of Hyptis suaveolens (L.) Poit. Essential Oil Nanoemulsion on Culex quinquefasciatus (Diptera: Culicidae)

Taires Peniche

Jonatas L. Duarte

Ricardo M. A. Ferreira

Igor A. P. Sidônio

Rosângela S. F. R. Sarquis

Ícaro R. Sarquis

Anna E. M. F. M. Oliveira

Rodrigo A. S. Cruz

Irlon M. Ferreira

Alexandro C. Florentino

José C. T. Carvalho

Raimundo N. P. Souto

and

Caio P. Fernandes

Molecules 2022, 27(23), 8433; https://doi.org/10.3390/molecules27238433 - 02 Dec 2022

Cited by 1 | Viewed by 1004

Abstract

Mosquitoes can be vectors of pathogens and transmit diseases to both animals and humans. Species of the genus Culex are part of the cycle of neglected diseases, especially Culex quinquefasciatus, which is an anthropophilic vector of lymphatic filariasis. Natural products can be an alternative to synthetic insecticides for vector control; however, the main issue is the poor water availability of some compounds from plant origin. In this context, nanoemulsions are kinetic stable delivery systems of great interest for lipophilic substances. The objective of this study was to investigate the larvicidal activity of the Hyptis suaveolens essential oil nanoemulsion on Cx. quinquefasciatus. The essential oil showed a predominance of monoterpenes with retention time (RT) lower than 15 min. The average size diameter of the emulsions (sorbitan monooleate/polysorbate 20) was ≤ 200 nm. The nanoemulsion showed high larvicidal activity in concentrations of 250 and 125 ppm. CL₅₀ values were 102.41 (77.5253–149.14) ppm and 70.8105 (44.5282–109.811) ppm after 24 and 48 h, respectively. The mortality rate in the surfactant control was lower than 9%. Scanning micrograph images showed changes in the larvae’s integument. This study achieved an active nanoemulsion on Cx. quinquefasciatus through a low-energy-input technique and without using potentially toxic organic solvents. Therefore, it expands the scope of possible applications of H. suaveolens essential oil in the production of high-added-value nanosystems for tropical disease vector control. Full article

(This article belongs to the Special Issue Chemistry of Phytocolloids)

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Open AccessArticle

Biocidal Activity of a Nanoemulsion Containing Essential Oil from Protium heptaphyllum Resin against Aedes aegypti (Diptera: Culicidae)

Cleidjane Gomes Faustino

Fernando Antônio de Medeiros

Allan Kardec Ribeiro Galardo

Alex Bruno Lobato Rodrigues

Anderson Luiz Pena da Costa

Rosany Lopes Martins

Lethicia Barreto Brandão

Lizandra Lima Santos

Marcos Antônio Alves de Medeiros

Patrick de Castro Cantuária

Ana Luzia Ferreira Farias

Jader Santos Cruz

and

Sheylla Susan Moreira da Silva de Almeida

Molecules 2021, 26(21), 6439; https://doi.org/10.3390/molecules26216439 - 25 Oct 2021

Cited by 3 | Viewed by 1141

Abstract

This work aimed to prepare a nanoemulsion containing the essential oil of the Protium heptaphyllum resin and evaluate its biocidal activities against the different stages of development of the Aedes aegypti mosquito. Ovicide, pupicide, adulticide and repellency assays were performed. The main constituents were p-cymene (27.70%) and α-pinene (22.31%). The developed nanoemulsion showed kinetic stability and monomodal distribution at a hydrophilic–lipophilic balance of 14 with a droplet size of 115.56 ± 1.68 nn and a zeta potential of −29.63 ± 3.46 mV. The nanoemulsion showed insecticidal action with LC₅₀ 0.404 µg·mL⁻¹ for the ovicidal effect. In the pupicidal test, at the concentration of 160 µg·mL⁻¹, 100% mortality was reached after 24 h. For adulticidal activity, a diagnostic concentration of 200 µg·mL⁻¹ (120 min) was determined. In the repellency test, a concentration of 200 µg·mL⁻¹ during the 180 min of the test showed a protection index of 77.67%. In conclusion, the nanobiotechnological product derived from the essential oil of P. heptaphyllum resin can be considered as a promising colloid that can be used to control infectious disease vectors through a wide range of possible modes of applications, probably as this bioactive delivery system may allow the optimal effect of the P. heptaphyllum terpenes in aqueous media and may also induce satisfactory delivery to air interfaces. Full article

(This article belongs to the Special Issue Chemistry of Phytocolloids)

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