Journal Description
Molbank
Molbank
is a peer-reviewed, open access journal comprised of a unique collection of one-compound-per-paper short notes on synthetic compounds and natural products. Molbank has been published online quarterly since 2009 (previously published irregularly).
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, ESCI (Web of Science), Reaxys, CAPlus / SciFinder, and other databases.
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 14.9 days after submission; acceptance to publication is undertaken in 2.6 days (median values for papers published in this journal in the first half of 2023).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
Impact Factor:
0.6 (2022)
Latest Articles
(E)-2-(1,3-Diphenylallyl)-3,5-dimethoxyphenol
Molbank 2023, 2023(3), M1709; https://doi.org/10.3390/M1709 - 04 Aug 2023
Abstract
►
Show Figures
The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The reaction proceeds smoothly to afford the mentioned compound in high yield under
[...] Read more.
The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The reaction proceeds smoothly to afford the mentioned compound in high yield under a metal and additive-free procedure. The corresponding allylated phenol has been fully characterized.
Full article
Open AccessShort Note
Isoamyl (E)-3-(3,4-Dimethoxyphenyl)acrylate
Molbank 2023, 2023(3), M1708; https://doi.org/10.3390/M1708 - 02 Aug 2023
Abstract
Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was obtained from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 min in dichloromethane with a yield of 95%. The structure of isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was elucidated using NMR,
[...] Read more.
Isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was obtained from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction at room temperature for 190 min in dichloromethane with a yield of 95%. The structure of isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) was elucidated using NMR, FTIR, and high-resolution mass spectrometry. In vitro sun protection factor evaluation exhibited a value of 37.10 ± 0.03 which indicates that isoamyl (E)-3-(3,4-dimethoxyphenyl)acrylate (1) is a sunscreen agent with high protection.
Full article
(This article belongs to the Section Organic Synthesis)
►▼
Show Figures
Scheme 1
Open AccessShort Note
N′-(5-Bromofuran-2-carbonyl)isonicotinohydrazide
Molbank 2023, 2023(3), M1706; https://doi.org/10.3390/M1706 - 01 Aug 2023
Abstract
N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1) was obtained in the form of a colorless solid from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction of 5-bromofuran-2-carboxylic acid and isoniazid in dichloromethane at room temperature with a yield of 83%. The structure of N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1
[...] Read more.
N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1) was obtained in the form of a colorless solid from the 2-methyl-6-nitrobenzoic anhydride (MNBA)/4-dimethylaminopyridine (DMAP)-catalyzed reaction of 5-bromofuran-2-carboxylic acid and isoniazid in dichloromethane at room temperature with a yield of 83%. The structure of N′-(5-bromofuran-2-carbonyl)isonicotinohydrazide (1) was elucidated using 1H NMR, 13C NMR, FTIR, and high-resolution mass spectrometry. Molecular docking screening of the title compound (1) on cyclooxygenase-2 (COX-2) protein (PDB ID: 5IKR) indicated that compound (1) has a good binding affinity, suggesting that further structure optimization and in-depth research can be carried out on compound (1) as a potential COX-2 inhibitor.
Full article
(This article belongs to the Section Organic Synthesis)
►▼
Show Figures
Figure 1
Open AccessCommunication
Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities
Molbank 2023, 2023(3), M1707; https://doi.org/10.3390/M1707 - 01 Aug 2023
Abstract
Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate. The anticancer properties of the compounds were studied in vitro.
Full article
(This article belongs to the Section Organic Synthesis)
►▼
Show Figures
Scheme 1
Open AccessShort Note
4-(4-ethoxyphenyl)-5-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
Molbank 2023, 2023(3), M1705; https://doi.org/10.3390/M1705 - 01 Aug 2023
Abstract
A new triazol-3-one resulted unexpectedly from the reduction reaction of a heterocyclic thioketone using sodium borohydride in pyridine containing a small amount of water. The structure of the new compound was characterised using FT-IR, 1D and 2D NMR, and HRMS spectroscopic methods.
Full article
(This article belongs to the Special Issue Molecules from Side Reactions II)
►▼
Show Figures
Graphical abstract
Open AccessCommunication
N-(((1S,5R)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-3-dodecan/tetradecanamido-N,N-dimethylpropan-1-aminium Bromide
by
, , , , , , , , , , , and
Molbank 2023, 2023(3), M1704; https://doi.org/10.3390/M1704 - 26 Jul 2023
Abstract
The syntheses of the title compounds were performed using lauric and myristic acids. The compounds obtained were characterized using 1H-, 13C-NMR and 2D 1H-1H COSY, 1H-13C HSQC NMR, IR, and high-resolution mass spectrometry. Both compounds
[...] Read more.
The syntheses of the title compounds were performed using lauric and myristic acids. The compounds obtained were characterized using 1H-, 13C-NMR and 2D 1H-1H COSY, 1H-13C HSQC NMR, IR, and high-resolution mass spectrometry. Both compounds exhibited bactericidal activity on S. aureus comparable to that of a reference drug (miramistin). Compound 10, with lauric acid fragment, had a 16-fold higher activity on P. aeruginosa compared to compound 11, which in turn contains myristic acid fragment (with minimum inhibitory concentrations of 32 and 512 μg/mL, respectively). Compound 11 exhibited a pronounced activity against all types of fungi (higher than the activity of miramistin), while the activity of compound 10 was considerably lower. Thus, compound 11 can serve as a promising antimicrobial agent for the treatment of various fungal and staphylococcal infections, while compound 10 is of interest to treat P. aeruginosa-associated infections.
Full article
(This article belongs to the Section Organic Synthesis)
►▼
Show Figures
Graphical abstract
attachment
Supplementary material:
Supplementary File 1 (ZIP, 622 KiB)
Supplementary File 2 (MOL, 5 KiB)
Supplementary File 3 (INCHI, 3 KiB)
Supplementary File 4 (MOL, 5 KiB)
Supplementary File 5 (MOL, 3 KiB)
Supplementary File 6 (INCHI, 2 KiB)
Supplementary File 7 (MOL, 4 KiB)
Supplementary File 8 (CIF, 1130 KiB)
Supplementary File 1 (ZIP, 622 KiB)
Supplementary File 2 (MOL, 5 KiB)
Supplementary File 3 (INCHI, 3 KiB)
Supplementary File 4 (MOL, 5 KiB)
Supplementary File 5 (MOL, 3 KiB)
Supplementary File 6 (INCHI, 2 KiB)
Supplementary File 7 (MOL, 4 KiB)
Supplementary File 8 (CIF, 1130 KiB)
Open AccessShort Note
2,7-Bis(pyridin-4-ylethynyl)-9H-carbazole
by
, , , , , , and
Molbank 2023, 2023(3), M1703; https://doi.org/10.3390/M1703 - 24 Jul 2023
Abstract
2,7-Bis(pyridin-4-ylethynyl)-9H-carbazole (1) was synthesized by reacting 4-ethynylpyridine hydrochloride with 2,7-dibromo-9H-carbazole. The full characterization of compound 1 is presented, and the crystal structure of its monohydrate was determined by single-crystal XRD analysis.
Full article
(This article belongs to the Section Structure Determination)
►▼
Show Figures
Graphical abstract
Open AccessShort Note
6,7-Dihydroxy-5,8-dimethoxy-2H-chromen-2-one
Molbank 2023, 2023(3), M1702; https://doi.org/10.3390/M1702 - 23 Jul 2023
Abstract
This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin. A high selectivity is achieved by using acetoxylation of methylenedioxy group with
[...] Read more.
This article presents a novel approach for synthesizing a new 5,8-dimethoxy derivative of esculetin via the selective cleavage of the methylene bridge in sabandin—naturally occurring and easily synthetically accessible methoxylated coumarin. A high selectivity is achieved by using acetoxylation of methylenedioxy group with lead tetraacetate. Natural coumarin sabandin as a starting compound was prepared in a few simple steps from 5-allyl-4,7-dimethoxybenzo[d][1,3]dioxole (apiol), which is readily available from parsley and dill seed extracts. The developed method enables an efficient and straightforward synthesis of a new derivative of esculetin with potential medicinal and therapeutic applications.
Full article
(This article belongs to the Section Organic Synthesis)
►▼
Show Figures
Graphical abstract
Open AccessShort Note
5-((4-(-Phenyldiazenyl)phenyl)diazenyl)quinolin-8-ol
Molbank 2023, 2023(3), M1701; https://doi.org/10.3390/M1701 - 21 Jul 2023
Abstract
►▼
Show Figures
A new azo compound was synthesized via an azo coupling reaction between 4-(phenyldiazenyl)benzenediazonium chloride and 8-hydroxyquinoline (8-Hq). The new diazene compound can be used to synthesize metal complexes as a derivative of 8-Hq. The structure of the new compound was characterized using UV–Vis,
[...] Read more.
A new azo compound was synthesized via an azo coupling reaction between 4-(phenyldiazenyl)benzenediazonium chloride and 8-hydroxyquinoline (8-Hq). The new diazene compound can be used to synthesize metal complexes as a derivative of 8-Hq. The structure of the new compound was characterized using UV–Vis, FT-IR, and 2D NMR spectroscopic methods.
Full article
Scheme 1
Open AccessShort Note
(2S,2’S,4R,5S,5’R)-2,2’-Di-tert-butyl-4-hydroxy-5,5’-dimethyl-4,5’-bi(1,3-dioxolanyl)-4’-one
Molbank 2023, 2023(3), M1699; https://doi.org/10.3390/M1699 - 20 Jul 2023
Abstract
The product formed by base-induced dimerisation of (2S,5S)-2-tert-butyl-5-methyl-1,3-dioxolan-4-one is shown by X-ray diffraction to be the title compound and not the isomeric fused-ring 1,3-dioxolane/1,3-dioxane-4-one structure proposed by previous researchers. The analogous compound derived from (2S,5S)-5-benzyl-2-tert-butyl-1,3-dioxolan-4-one has also been obtained and characterised.
Full article
(This article belongs to the Section Structure Determination)
►▼
Show Figures
Graphical abstract
Open AccessShort Note
4-(2,5-Dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine
Molbank 2023, 2023(3), M1700; https://doi.org/10.3390/M1700 - 20 Jul 2023
Abstract
1,2,5-Oxadiazol-3-amines with a heterocyclic substituent in the 4-position are being intensively investigated as compounds with valuable pharmacological activity. In this communication, the reaction of 1,2,5-oxadiazole-3,4-diamine with 2,5-hexanedione was shown to selectively give 4-(2,5-dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine as a product of the Paal–Knorr reaction. The
[...] Read more.
1,2,5-Oxadiazol-3-amines with a heterocyclic substituent in the 4-position are being intensively investigated as compounds with valuable pharmacological activity. In this communication, the reaction of 1,2,5-oxadiazole-3,4-diamine with 2,5-hexanedione was shown to selectively give 4-(2,5-dimethyl-1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-amine as a product of the Paal–Knorr reaction. The structure of the synthesized compound was established by elemental analysis, high-resolution mass spectrometry, 1H and 13C NMR, and IR spectroscopy.
Full article
(This article belongs to the Collection Heterocycle Reactions)
►▼
Show Figures
Scheme 1
Open AccessShort Note
Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate
Molbank 2023, 2023(3), M1697; https://doi.org/10.3390/M1697 - 19 Jul 2023
Abstract
Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation
[...] Read more.
Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.
Full article
(This article belongs to the Section Natural Products)
►▼
Show Figures
Figure 1
Open AccessShort Note
[μ-1,2-Bis(dipheylphosphino)ethane-κ2P,P’]bis(3-mercapto-1,2-propanediolato-κS-gold(I))
by
and
Molbank 2023, 2023(3), M1698; https://doi.org/10.3390/M1698 - 19 Jul 2023
Abstract
►▼
Show Figures
A new dinuclear gold(I) complex, possessing a bridging diphosphine ligand (1,2-bis(diphenylphosphino)ethane) and two terminal thiol ligands (1-thioglycerol), was synthesized and fully characterized by IR, 1H and 31P NMR, fluorescence, ESI-mass, and diffuse reflection spectroscopy, together with X-ray diffraction and elemental analyses.
[...] Read more.
A new dinuclear gold(I) complex, possessing a bridging diphosphine ligand (1,2-bis(diphenylphosphino)ethane) and two terminal thiol ligands (1-thioglycerol), was synthesized and fully characterized by IR, 1H and 31P NMR, fluorescence, ESI-mass, and diffuse reflection spectroscopy, together with X-ray diffraction and elemental analyses. The compound formed a 1D chain supramolecular structure through intermolecular aurophilic interactions in the crystal structure, leading to photoluminescence in the solid state.
Full article
Figure 1
Open AccessShort Note
1-[(1S)-(4-Fluorophenyl)-((1′S)-1′-naphthalen-1-yl-ethylamino)-methyl]-naphthalen-2-trifluoromethanesulfonate
Molbank 2023, 2023(3), M1695; https://doi.org/10.3390/M1695 - 14 Jul 2023
Abstract
The complex structure of aminobenzylnaphthols can be easily obtained with the useful Betti reaction. These valuable compounds can give rise to chiral intermediates, that found wide application in asymmetric synthesis. 1-[(1S)-(4-Fluorophenyl)-((1′S)-1′-naphthalen-1-yl-ethylamino)-methyl]-naphthalen-2-ol 1 was treated with triflic anhydride to yield
[...] Read more.
The complex structure of aminobenzylnaphthols can be easily obtained with the useful Betti reaction. These valuable compounds can give rise to chiral intermediates, that found wide application in asymmetric synthesis. 1-[(1S)-(4-Fluorophenyl)-((1′S)-1′-naphthalen-1-yl-ethylamino)-methyl]-naphthalen-2-ol 1 was treated with triflic anhydride to yield the corresponding (S,S)-triflate 2, which is a valuable intermediate in the future synthesis of aminophosphine, to be used in asymmetric catalysis. Preliminarily structural considerations based upon H(1)-NMR spectroscopy are also reported.
Full article
(This article belongs to the Collection Molecules from Catalytic Processes)
►▼
Show Figures
Scheme 1
Open AccessShort Note
28-O-Acetyl-3-O′-(prop-2-enoyl)betulin
Molbank 2023, 2023(3), M1696; https://doi.org/10.3390/M1696 - 14 Jul 2023
Abstract
►▼
Show Figures
28-Acetylbetulin is a good starting compound for the synthesis of 3- or 3,28-substituted betulin derivatives with biological activity. The final product of the reaction of 28-acetylbetulin and acrylic acid under Steglich esterification conditions produced a new 3-alkenyl betulin derivative. The structure of the
[...] Read more.
28-Acetylbetulin is a good starting compound for the synthesis of 3- or 3,28-substituted betulin derivatives with biological activity. The final product of the reaction of 28-acetylbetulin and acrylic acid under Steglich esterification conditions produced a new 3-alkenyl betulin derivative. The structure of the obtained compound was confirmed based on the analysis of NMR, IR, EI MS, and HRMS spectra. Selected pharmacokinetic parameters related to the absorption and distribution were calculated for the new betulin derivative using in silico methods.
Full article
Figure 1
Open AccessShort Note
3-(4-(Benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine
Molbank 2023, 2023(3), M1694; https://doi.org/10.3390/M1694 - 12 Jul 2023
Abstract
The [1,2,4]triazolo[4,3-a]pyridine derivative 3-(4-(benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine was prepared in a 73% isolated yield by means of an oxidative ring closure of a hydrazine intermediate. Sodium hypochlorite was used as the oxidant and ethanol as a solvent, making the process a clean,
[...] Read more.
The [1,2,4]triazolo[4,3-a]pyridine derivative 3-(4-(benzyloxy)-3-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine was prepared in a 73% isolated yield by means of an oxidative ring closure of a hydrazine intermediate. Sodium hypochlorite was used as the oxidant and ethanol as a solvent, making the process a clean, green approach. The reaction was performed at room temperature for 3 h, and then the heterocycle was isolated in an analytically pure form by extraction, followed by passing the crude product mixture through a small plug of alumina.
Full article
(This article belongs to the Collection Heterocycle Reactions)
►▼
Show Figures
Graphical abstract
Open AccessShort Note
2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one
by
, , , , , and
Molbank 2023, 2023(3), M1693; https://doi.org/10.3390/M1693 - 10 Jul 2023
Abstract
The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3-triazol-4-yl)methanamine, 2-isocyano-1-morpholino-3-phenylpropan-1-one, and maleic anhydride under a microwave-assisted one-pot process [Ugi-Zhu/aza Diels-Alder cycloaddition/N-acylation/decarboxylation/dehydration] with a 28% overall yield. The synthesized
[...] Read more.
The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3-triazol-4-yl)methanamine, 2-isocyano-1-morpholino-3-phenylpropan-1-one, and maleic anhydride under a microwave-assisted one-pot process [Ugi-Zhu/aza Diels-Alder cycloaddition/N-acylation/decarboxylation/dehydration] with a 28% overall yield. The synthesized compound was fully characterized by 1D (1H, 13C) and 2D (COSY, HSQC, and HMBC) NMR, FT-IR, and HRMS.
Full article
(This article belongs to the Collection Heterocycle Reactions)
►▼
Show Figures
Graphical abstract
Open AccessCommunication
Synthesis, Crystal Structure and Anti-Leukemic Activity of (E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
by
, , , , , , and
Molbank 2023, 2023(3), M1691; https://doi.org/10.3390/M1691 - 08 Jul 2023
Abstract
(E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one was designed then synthesized using a multi-step pathway starting from commercially available 2-nitroaniline. Structure characterization of this original substituted pyrrolo[1,2-a]quinoxaline compound was achieved by using FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This
[...] Read more.
(E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one was designed then synthesized using a multi-step pathway starting from commercially available 2-nitroaniline. Structure characterization of this original substituted pyrrolo[1,2-a]quinoxaline compound was achieved by using FT-IR, 1H-NMR, 13C-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline shows interesting cytotoxic potential against different human leukemia cell lines (MV4-11, K562, MOLM14 and Jurkat cells).
Full article
(This article belongs to the Section Organic Synthesis)
►▼
Show Figures
Figure 1
attachment
Supplementary material:
Supplementary File 1 (ZIP, 801 KiB)
Supplementary File 2 (MOL, 2 KiB)
Supplementary File 3 (INCHI, 690 B)
Supplementary File 4 (MOL, 2 KiB)
Supplementary File 5 (MOL, 2 KiB)
Supplementary File 6 (INCHI, 721 B)
Supplementary File 7 (MOL, 2 KiB)
Supplementary File 8 (CIF, 690 KiB)
Supplementary File 1 (ZIP, 801 KiB)
Supplementary File 2 (MOL, 2 KiB)
Supplementary File 3 (INCHI, 690 B)
Supplementary File 4 (MOL, 2 KiB)
Supplementary File 5 (MOL, 2 KiB)
Supplementary File 6 (INCHI, 721 B)
Supplementary File 7 (MOL, 2 KiB)
Supplementary File 8 (CIF, 690 KiB)
Open AccessCommunication
Synthesis, Characterization and Chlorination of 4-(Pentyloxy)-7-(prop-2-yn-1-yloxy)pteridin-2-amine
Molbank 2023, 2023(3), M1692; https://doi.org/10.3390/M1692 - 08 Jul 2023
Abstract
A new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride. The purity and chemical structure of the compound was validated by NMR (1H, 13C) spectroscopy, Mass (APCI source)
[...] Read more.
A new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride. The purity and chemical structure of the compound was validated by NMR (1H, 13C) spectroscopy, Mass (APCI source) spectrometry, elemental analysis, and X-ray crystallography. The title compound may be further functionalized by exploiting the yne moiety, for instance, using click chemistry. The novel pterin derivative, most notably, in contrast to typical pterin behavior, is now soluble or even well soluble in almost any solvent except water.
Full article
(This article belongs to the Collection Heterocycle Reactions)
►▼
Show Figures
Figure 1
Open AccessShort Note
Bis(μ2-2,2′-((2-(hydroxy)propane-1,3-diyl)bis((nitrilo)eth-1-yl-1-ylidene))diphenolato)-dicobalt(III)
Molbank 2023, 2023(3), M1690; https://doi.org/10.3390/M1690 - 07 Jul 2023
Abstract
A new cobalt(III) complex with a pentadentate Schiff base was synthesized using a reaction of 2,2′-{(2-hydroxypropane-1,3-diyl)bis(nitriloeth-1-yl-1-ylidene)}diphenol (H3L) and cobalt(II) acetate in a methanolic solution. This synthesis resulted in the isolation of dinuclear compound [CoIII2L2] (1
[...] Read more.
A new cobalt(III) complex with a pentadentate Schiff base was synthesized using a reaction of 2,2′-{(2-hydroxypropane-1,3-diyl)bis(nitriloeth-1-yl-1-ylidene)}diphenol (H3L) and cobalt(II) acetate in a methanolic solution. This synthesis resulted in the isolation of dinuclear compound [CoIII2L2] (1), which was characterized using elemental analyses and XRF, FTIR, and TG/DSC techniques. The molecular structure of the complex was confirmed using single-crystal X-ray diffraction. The structure of 1 consists of a centrosymmetric dimer in which two crystallographically equivalent cobalt(III) ions are bridged by two alkoxido oxygen atoms. In addition, each metal center is coordinated by two Schiff bases.
Full article
(This article belongs to the Section Structure Determination)
►▼
Show Figures
Figure 1
Highly Accessed Articles
Latest Books
E-Mail Alert
News
Topics
Topic in
Catalysts, Chemistry, Materials, Molbank, Molecules
Catalysis: Homogeneous and Heterogeneous
Topic Editors: Maria Luisa Di Gioia, Luísa Margarida Martins, Isidro M. PastorDeadline: 31 August 2023
Topic in
Catalysts, Chemistry, Molbank, Molecules, Sustainable Chemistry
Towards the Sustainable Synthesis of Biologically Active Molecules in Green Solvents
Topic Editors: Antonio Salomone, Serena PerroneDeadline: 31 December 2024
Conferences
Special Issues
Special Issue in
Molbank
Molecules from Side Reactions II
Guest Editors: Stefano D’Errico, Annalisa GuaragnaDeadline: 31 August 2023